HPV test results are not black and white and depend on which test has been carried out and what cut-off level was used (Cubie & Cuschieri 2013).
Although high-risk HPV positivity may support an equivocal cytology result (e.g. ASC-H or HSIL vs. immature metaplasia) it cannot prove its nature in the absence of other evidence (e.g. colposcopic findings or punch biopsy).
The low PPV of high-risk HPV-positivity must be taken into account (e.g. Moss et al. 2013: 4-12% for CIN3+ and 12-23% for CIN2+).
High-risk HPV is not uniformly found in high-grade CIN or cancer. Its sensitivity for CIN2+ and CIN3+ is usually higher than cytology but its sensitivity is in the range of 85-95%.
HPV status of cases at MDT meetings