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Epithelial / myoepithelial carcinoma

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The tumor is composed of two cell types which form duct-like structures: ductal cells (inner layer), clear myoepithelial cells (outer layer). They can be distinguished by immunocytochemistry: the former are pan-keratin positive, the latter are S-100 positive. The cytology is that of a malignant clear cell tumor, with varying degrees of cellular and nuclear atypia. There are both tissue fragments and isolated cells; the cells may be arranged in solid and papillary structures. The stromal component is metachromatic, with a hyaline, elongated appearance. In some occasions duct-like or globular structures are also found. The cytological pattern suggests a malignant growth.

Epimyoepithelial carcinoma

Using low power the sheets look basaloid again, some cylindromatous metachromatic fragments are present ( Giemsa stain ). High magnification shows the clear myoepithelial character of these cells, the inner cells are somewhat smaller, the outer zone cells do have finely granular/foamy or clear cytoplasm. In some cases either cell type is dominant and shows evident signs of malignancy. In general the cytology does not suggest highly malignant change!
Using low power the sheets look basaloid again, some cylindromatous metachromatic fragments are present ( Giemsa stain ). High magnification shows the clear myoepithelial character of these cells, the inner cells are somewhat smaller, the outer zone cells do have finely granular/foamy or clear cytoplasm. In some cases either cell type is dominant and shows evident signs of malignancy. In general the cytology does not suggest highly malignant change!
Using low power the sheets look basaloid again, some cylindromatous metachromatic fragments are present ( Giemsa stain ). High magnification shows the clear myoepithelial character of these cells, the inner cells are somewhat smaller, the outer zone cells do have finely granular/foamy or clear cytoplasm. In some cases either cell type is dominant and shows evident signs of malignancy. In general the cytology does not suggest highly malignant change!
Using low power the sheets look basaloid again, some cylindromatous metachromatic fragments are present ( Giemsa stain ). High magnification shows the clear myoepithelial character of these cells, the inner cells are somewhat smaller, the outer zone cells do have finely granular/foamy or clear cytoplasm. In some cases either cell type is dominant and shows evident signs of malignancy. In general the cytology does not suggest highly malignant change!

 

The morphology of the myoepithelial cells is evident on histology: the cells are arranged in groups, they show S100, PanCK positivity. The smear shows the presence of polymorphic myoepithelia cells mixed up with normal, large salivary gland acinic cells.
The morphology of the myoepithelial cells is evident on histology: the cells are arranged in groups, they show S100, PanCK positivity. The smear shows the presence of polymorphic myoepithelia cells mixed up with normal, large salivary gland acinic cells.
The morphology of the myoepithelial cells is evident on histology: the cells are arranged in groups, they show S100, PanCK positivity. The smear shows the presence of polymorphic myoepithelia cells mixed up with normal, large salivary gland acinic cells.

 

Malignant myoepithelioma

 

The structure of the lesion is malignant on histology: invasion is found. The cells are enlarged, different in size and shape. Foamy cells may be present, extremely dedifferentiated tumors also may occur.
The cytology shows enlarged cells, with large ovoid nucleus, uneven chromatin. Sometimes „squamoid” differentiation is taking place (A) (Giemsa stain).The cells are vulnerable, as a consequence of producing the smear, elongated, irregularly shaped nuclei will be produced (B).
The structure of the lesion is malignant on histology: invasion is found. The cells are enlarged, different in size and shape. Foamy cells may be present, extremely dedifferentiated tumors also may occur.
The cytology shows enlarged cells, with large ovoid nucleus, uneven chromatin. Sometimes „squamoid” differentiation is taking place (A) (Giemsa stain).The cells are vulnerable, as a consequence of producing the smear, elongated, irregularly shaped nuclei will be produced (B).

 

The same tumor as on the previous views: the shape of the nuclei is typical. Some intranuclear (pseudo) vacuoles (A) are visible. The cytoplasm in some cells squamoid (B) in others granular (C).
The same tumor as on the previous views: the shape of the nuclei is typical. Some intranuclear (pseudo) vacuoles (A) are visible. The cytoplasm in some cells squamoid (B) in others granular (C).