Evaluación de la muestra

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Varias características se deben considerar en la evaluación de una muestra:

El tipo de célula (tal como célula tiroidea, macrófagos, linfocitos)

**Thyrocytes and macrophages.** Fluid colloid in the background, bland thyrocytes and pigmented macrophages.

**Lymphocytes and thyrocytes.** A group of bland thyroid cells showing a follicular arrangement, surrounded by smaller lymphoid cells with little amount of identifiable cytoplasm. Such lymphoid cells are also inside the follicular group, suggesting chronic inflammation.

La cantidad y tipo de coloide (escaso-abundante, fluido-denso)

**Colloid:** Fluid but relatively thick colloid with the typical cracks which are produced with air drying. These are artefacts which are useful in recognising colloid.

**Colloid:** A clump of thicker colloid surrounded by few bare nuclei. In the appropriate context this type of colloid may be associated with papillary carcinoma.

La celularidad (escasa, moderada o marcada)

**Highly cellular smear showing a microbiopsy.** A microbiopsy, as may be obtained with larger needles, in which 3D follicles are separated by collagenous septa; the margins of the follicles are regular. This pattern is usually seen in FNAs from nodular goitres. Please note that in air dried samples stained with MGG the centre of these microbiopsies will be too thick to assess.

Less cellular but diagnostic smear showing groups of bland thyroid cells in a microfollicular arrangement, bare nuclei of thyroid cells and fluid colloid in the background. A few macrophages are also present. This pattern is associated with benign disease.

La arquitectura (monocapas, grupos apiñados, sábanas, macro/microfolículos, grupos papilares, células aisladas)

**Sheets of bland thyroid cells.** A monolayered sheet of bland thyroid cells. Note the regular distribution of the nuclei and cytoplasm and very fine chromatin with small nucleoli.

**Sheets of bland thyroid cells.** Another example of a a monolayered sheet of bland thyroid cells. Because of the size of this sheet some areas may appear more crowded but are actually simply folded. It is good practice to focus on these areas to check the regular distribution of cells along the same plane. Such large sheets are usually lining larger follicles or cysts in benign disease.

**Thyroid cells in a microfollicular arrangement.** Several groups of thyroid cells in a microfollicular arrangement. In follicular lesions this may be the only type of cell present.

**A papillary cluster** with the epithelial cells lying perpendicular to the stromal axis. The typical nuclear features of papillary carcinoma need to be present however for a diagnosis of papillary carcinoma..

La presencia de núcleos desnudos

Many bare nuclei are seen dispersed together with bland thyroid cells in a follicular arrangement. Note that the chromatin pattern is the same, confirming that these nuclei have been stripped of their fragile cytoplasm during the smearing procedure. Lymphocytes are smaller, have a more granular chromatin, folded nuclear membrane and scanty but clearly identifiable, dense cytoplasm.

Características citológicas (citoplasma, núcleo)

En lesiones neoplásicas las muestras son con frecuencia altamente celulares. Las sábanas planas son comunes en el bocio y los adenomas macrofoliculares, pero pueden también estar presentes en carcinomas. Los macrofolículos están usualmente asociados con el bocio multinodular y los adenomas macrofoliculares. Un predominio de microfolículos puede ser sugestivo de neoplasia folicular. Los grupos papilares, con células recubriendo un tallo fibrovascular, son característicos del carcinoma papilar. Los frotis con una alta proporción de coloide a células foliculares usualmente es indicativo de un nódulo benigno.