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Liver cell adenoma

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Liver cell adenoma

It is an uncommon benign tumor, usually occurring in women under the age of 30 who have a history of use of oral contraceptives. Histologically, they are only composed of hepatocytes.

Cytologic diagnostic features

  • Predominance of hepatocytes
  • Mild nuclear atypia
  • Abundant cytoplasm
  • Normal N/C ratio

Differential diagnosis

  • Normal liver
  • Focal nodular hyperplasia
  • Regenerating nodules in cirrhosis
  • Hepatocellular carcinoma

It has been suggested that the absence of bile duct epithelium supports a diagnosis of hepatic adenoma excluding focal nodular hyperplasia. The cells of hepatocellular carcinoma have a higher N/C ratio and more nuclear atypia.