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Epithelioid hemangioendothelioma

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Epithelioid hemangioendothelioma

  • Hypocellular (in some cases)
  • Isolated, large polymorphous cells with a folded nuclear outline
  • Occasional intranuclear and cytoplasmic inclusions
  • Binucleated and multinucleated giant cells
  • Round irregular nuclei, prominent nucleoli
  • Abundant lacy and hematoxiphilic cytoplasm

Immunostains for endothelial markers are usually positive.