Course Area: Paediatric Cytology

Juvenile granulose cell tumours

Clinical features Fig 101 – Juvenile granulosa cell tumor- Loose clusters of homogeneous neoplastic cells (H&E) Immunocytochemistry Electron microscopy Genetic studies Differential diagnosis Main points

Nasopharyngeal carcinoma

Clinical features Fig 104a –  Nasopharyngeal carcinoma – Sheets of undifferentiated epithelial cells, with high nuclear/cytoplasmic ratio, vesicular nuclei and prominent nucleoli (H&E) Immunocytochemistry Genetic studies Differential diagnosis Main points

Adrenal cortical adenoma/carcinoma

Clinical features Fig 97 – Adrenal cortical adenoma/ carcinoma – Fine needle aspiration from an adrenal adenoma. Cellular smear with discohesive neoplastic cells with bland nuclei (H&E) Immunocytochemistry Differential diagnosis   Main points

Pheochromocytoma

Clinical features Cytopathology Immunocytochemistry Genetic studies Differential diagnosis Main points

Langerhans Histiocytosis

For details see Histiocytic lesions Clinical features Cytopathology For details see Histiocytic lesions The authors do not have any experience of fine needle aspiration in this particular presentation in children. Immunocytochemistry For details see Histiocytic lesions Modern Techniques of Diagnosis For details see Histiocytic lesions Differential Diagnosis Main points

Hamartoma

Clinical features Fig 88 – Lung Hamartoma Smear from a transthoracic guided fine needle aspiration, Fragment of mesenchyma in a myxoid matrix. (H&E) Immunocytochemistry No contributory Modern Techniques of Diagnosis No contributory Differential Diagnosis

Inflammatory pseudo tumour

Clinical features Fig 91 – Inflammatory pseudotumor – Smear from a transthoracic guided fine needle aspiration – Poorly cohesive polymorphic population (fibroblasts, Histiocytes, lymphocytes and plasma cells) (H&E) Immunocytochemistry Modern Techniques of Diagnosis Non contributory Differential Diagnosis Main points