This content is also available in: English Italiano Español Magyar Polski

Bookmark (0)

No account yet? Register

Cytologická diagnóza invazivního endocervikálního adenokarcinomu

Adenocarcinoma in situ:

Cervical scrapes from a focus of AIS are often very cellular containing numerous sheets of glandular cells. This in itself should raise suspicion of glandular neoplasia unless the specimen has been taken with an endocervical  brush. In this slide the nuclei are crowded , hyperchromatic but their columnar shape can be readily recognised.Note the clean background. Sheets of normal endocervical epithelium were also found in the smear. Note clean background.
A cluster of neoplastic cells  from a focus of AIS. There is some loss of polarity, variation in nuclear size and an obvious nuclear hyperchromasia but the honeycomb pattern can still be discerned. The distinction between AIS and invasive adenocarcinoma cannot be made with a high degree of certainty

Dob?e diferencovaný endocervikální adenokarcinom

Endocervical adenocarcinoma; Sheet of glandular cells in cervical smear showing “feathering “ and palisade formation at the edges of the sheet.
Adenocarcinoma showing palisade formation at higher magnification Note uneven distribution of the nuclei in the palisade
Endocervical adenocarcinoma :Strips of crowded columnar cells showing pseudostratifiction with dense overlapping nuclei but the glandular architecture is still preserved.
Invasive endocervical adenocarcinoma: a three dimensional cluster of glandular cells. Apart from the background the morphology is similar  to that found in AIS
Endocervical adenocarcinoma (poorly differentiated) Nuclei are large pleomorphic with irregular chromatin and the cytoplasm is abundant and delicate but little of the glandular architecture is retained.

Metastatický endocervikální adenokarcinom

Other malignant neoplasms: Endometrial carcinoma in a cervical smear
Other malignant neoplasms: Metastatic colon adenocarcinoma in a cervical smear
Endocervical adenocarcinoma(poorly differentiated): The cluster is composed of undifferentiated tumour cells with scant cytoplasm and nuclei which vary in size. The delicate chromatin structure of the nuclei and the macronucleoli are consistent with adenocarcinoma.
Other malignant neoplasms: Ovarian carcinoma in a cervical smears

Špatn? diferencované endocervikální adenokarcinomy

Endocervical adenocarcinoma:There is little to distinguish this hyperchromatic cluster of malignant glandular cells form those found in a  poorly differentiated squamous carcinoma.