Primary effusion lymphoma
It is a large B-cell lymphoma which presents as a pleural, pericardial or peritoneal effusion. There is no associated mass lesion or lymphadenopaty. Most cases arise in the setting of HIV infection. The prognosis is poor.
Cytologic diagnostic features
- Dispersed large cells
- Round or irregular nuclei, prominent nucleoli
- Abundant basophilic cytoplasm (Romanowsky stain)
Flow Cytometry on a fresh sample confirms the morphological findings