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By definition, large cell undifferentiated carcinoma lacks the microscopic features of the other lung carcinomas, therefore this diagnosis is made by exclusion. It accounts for about 10% of all lung cancers and it is most commonly located peripherally. Histologically, these tumors are characterized by sheets and nests of large cells with vesicular nuclei and prominent nucleoli.
The cytologic diagnosis of malignancy in large cell undifferentiated carcinoma is not difficult.

Rare variants:

Cytologic diagnostic features

Differential diagnosis

Necrotic large cell carcinoma:

Necrotic large cell carcinoma
Necrotic large cell carcinoma (sputum)