Myeloid metaplasia
Myeloid metaplasia Myeloid metaplasia may occur mainly in cases of myelofibrosis and myeloproliferative syndromes but may be observed in different pathological condictions such as lymphomas, previous infective diseases or after chemotherapies. The hallmark of this condition is the presence of megakaryocytes, which may be isolated or attached to PALS. Myeloid metaplasia causing diffuse splenomegaly […]
Granulomatous processes
Granulomatous processes Sarcoidosis and tuberculosis and other infective diseases may cause granulomatous lesions to the spleen. Hodgkin and non Hodgkin lymphoma and chemotherapy may be followed by granulomatous lesions which may cause equivocal clinical features. Epithelioid cells (left) and granulomatous structure in a hematic background in a splenomegaly developed in a NHL patient in remission. […]
Storage diseases
Storage diseases Splenic FNA of storage diseases showing numerous histiocytes with large, pale, bubbly cytoplasm, dispersed or attached to PALS edges. Cytoplasm is typically pinkish or with many small lipidic droplets.
Spleen
General Nodular or diffuse splemomegalies may be determined by several causes; in most cases, clinical and serological data are diagnostic but there are still rare conditions or equivocal clinical presentations in which a direct evaluation may be useful. FNC of the spleen was first used for the diagnosis of leishmaniasis and was then extensively used […]