Nephroblastoma (Wilms’ tumour)
linical features Fig 4a – Wilms ‘tumor-Blastema cells- Loose small round cells with fine chromatin and inconspicuous nucleoli a)-Giemsa- remark nuclei moulding , given the scarcity of cytoplasm Classically, a triphasic morphologic pattern may be present in differing proportions: Immunocytochemistry Genetic studies: Differential diagnosis Main points
Congenital mesoblastic nephroma
Clinical features Fig1- Congenital Mesoblastic Nephroma- cohesive fragments o fibroblastic/myofibroblastic cells in a clear background (H&E) Attention is required regarding entrapped renal tubules of periphery, or even deeper situated in the tumour, which can acquire primitive appearance-(embryonal metaplasia-Fig 3). Entrapped tubules are EMA positive and CD56 (NCAM) negative. These antibodies are helpful in the distinction between mature […]
I – RENAL NEOPLASMS
I – RENAL NEOPLASMS
INTRODUCTION
INTRODUCTION The approach to the cytological diagnostic of tumours and pseudotumoral lesions in paediatrics is based essentially on the use of fine-needle biopsy (FNB). Being an inexpensive low invasive technique with a high accuracy and diagnostic briefness FNB is regarded ideal to be applied in the paediatric setting and particularly in underdeveloped countries. Cytogenetic and […]