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Primary adenocarcinoma is rare: approximately 2% of all primary urothelial tumors.
Adenocarcinoma voided urine
- Clusters of cuboidal or columnar cells
- Large, irregular and hyperchromatic nuclei
- Vacuolated cytoplasm
- The vacuole is often large, single and pushes the nucleus towards the cell periphery
- The nuclei tend to be vesicular
- Large nucleoli and dense chromatin strands
- Mucin-secreting, signet-ring cell and clear cell adenocarcinomas can also be seen
Adenocarcinoma bladder washings
- Large variations in nuclear size
- Large nuclei without cytoplasm
- Nuclei with irregular shape and bizarre nucleoli
- Usually hyperchromatic nuclei with clumped chromatin but hypochromatic nuclei can also be seen
- Marked increasing of the nuclear-cytoplasmic ratio
- Dissociated tumour cells
Urinary adenocarcinoma image library
