{"id":6178,"date":"2023-03-17T08:42:45","date_gmt":"2023-03-17T08:42:45","guid":{"rendered":"https:\/\/www.eurocytology.eu\/course\/tumor-misto\/"},"modified":"2023-04-26T09:31:31","modified_gmt":"2023-04-26T09:31:31","slug":"tumor-misto","status":"publish","type":"course","link":"https:\/\/www.eurocytology.eu\/pt-pt\/course\/cabeca-e-pescoco-up-to-date-2015\/tumores-benignos-das-glandulas-salivares\/tumor-misto\/","title":{"rendered":"Tumor misto"},"content":{"rendered":"<div data-object_id=\"6178\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/pt-pt\/wp-json\/wp\/v2\/course\/6178\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"6178\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"6178\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-6178\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nome de utilizador ou endere\u00e7o de email<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Senha<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Manter sess\u00e3o<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Iniciar sess\u00e3o\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/pt-pt\/wp-json\/wp\/v2\/course\/6178\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/pt-pt\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fpt-pt%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F6178%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>Este tumor \u00e9 tamb\u00e9m chamado de Adenoma pleom\u00f3rfico por ter uma estrutura composta. \u00c9 constitu\u00eddo por elementos mioepiteliais, em alguns casos podem se diferenciar em c\u00e9lulas escamosas queratinizadas ou estruturas glandulares, em conjunto com um componente do estroma. As c\u00e9lulas mioepiteliais podem ser plasmocitoides ou epitelioides. A forma\u00e7\u00e3o de cistos pode ocorrer. O estroma pode ser condroide, hialinizado, fibr\u00f3tico ou mesmo \u00f3sseo, geralmente muito acelular. \u00c9 o tumor mais comum das gl\u00e2ndulas salivares, compreendendo 60-70% de todos os tumores de gl\u00e2ndulas salivares, e surgem mais frequentemente em mulheres. A estrutura complexa do tumor d\u00e1 origem, por vezes, ao aspecto citol\u00f3gico polimorfo e complexo. Utilizando o corante Giemsa o componente do estroma condromixoide \u00e9 metacrom\u00e1tico permitindo um f\u00e1cil diagn\u00f3stico. O estroma condromixoide mostra a presen\u00e7a de fios finos, p\u00e1lidos num padr\u00e3o irregularmente organizado. Este tipo de estroma \u00e9 diagn\u00f3stico e parece ser muito semelhante ao encontrado no estroma do Cordoma, tumor raro, que pode ser localizado na \u00e1rea da nasofaringe. Os fios acima mencionados normalmente n\u00e3o s\u00e3o vistos em um Carcinoma aden\u00f3ide c\u00edstico. O encontro de poucas c\u00e9lulas epiteliais at\u00edpicas n\u00e3o significa a transforma\u00e7\u00e3o maligna; ainda h\u00e1 um conhecido Tumor maligno misto \u201cin situ\u201d, que exibe grupos de c\u00e9lulas epiteliais at\u00edpicas, evidentemente, misturadas com o mioepit\u00e9lio. Quanto mais monom\u00f3rfico o aspecto celular, mais \u00e9 sugestivo de altera\u00e7\u00e3o maligna precoce.<\/p>\n<p>8 &#8211; 9% dos Tumores mistos podem sofrer transforma\u00e7\u00e3o maligna, ap\u00f3s 15 &#8211; 25 anos; o resultado \u00e9 um Tumor maligno altamente invasivo, geralmente Carcinoma de c\u00e9lulas escamosas ou Carcinoma indiferenciado. Em ocasi\u00f5es muito raras Sarcomas fusocelulares ou at\u00e9 mesmo Carcinossarcoma podem ser encontrado. A malignidade citol\u00f3gica destes tumores \u00e9 geralmente f\u00e1cil de reconhecer.<\/p>\n<p>&nbsp;<\/p>\n<figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img fetchpriority=\"high\" decoding=\"async\" alt=\"\" height=\"396\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2440_1442751799.jpg?itok=yJd4CEQ5\" width=\"613\" \/><\/a><figcaption>Hitologia(H&amp;E): c\u00e9lulas mioepiteeliais com v\u00e1rias diferencia\u00e7\u00f5es ( tipo comum, glandular, escamosa, etc, (A) e &nbsp;estroma que pode ser fibr\u00f3tico, mucinoso, condroide. ( B ).<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"492\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2441_1442751820.jpg?itok=PTxJiqlT\" width=\"657\" \/><\/a><figcaption>Hitologia(H&amp;E): c\u00e9lulas mioepiteeliais com v\u00e1rias diferencia\u00e7\u00f5es ( tipo comum, glandular, escamosa, etc, (A) e &nbsp;estroma que pode ser fibr\u00f3tico, mucinoso, condroide. ( B ).<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"363\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2443_1442751892.jpg?itok=has9_kK2\" width=\"551\" \/><\/a><figcaption>De novo: vantagem do Giemsa. &nbsp;O fundo (estroma ) \u00e9 metacrom\u00e1tico, p\u00farpura, n\u00facleos grandes de c\u00e9lulas mioepiteliais envoltos no estroma. Em partes do estroma s\u00e3o vistas faixas deste n\u00e3o coradas, que s\u00e3o t\u00edpicas destas les\u00f5es(setas).<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"375\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2444_1442751913.jpg?itok=RyfHcqHm\" width=\"565\" \/><\/a><figcaption>De novo: vantagem do Giemsa. &nbsp;O fundo (estroma ) \u00e9 metacrom\u00e1tico, p\u00farpura, n\u00facleos grandes de c\u00e9lulas mioepiteliais envoltos no estroma. Em partes do estroma s\u00e3o vistas faixas deste n\u00e3o coradas, que s\u00e3o t\u00edpicas destas les\u00f5es(setas).<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"346\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2445_1442751934.jpg?itok=NeEzxiXu\" width=\"529\" \/><\/a><figcaption>De novo: vantagem do Giemsa. &nbsp;O fundo (estroma ) \u00e9 metacrom\u00e1tico, p\u00farpura, n\u00facleos grandes de c\u00e9lulas mioepiteliais envoltos no estroma. Em partes do estroma s\u00e3o vistas faixas deste n\u00e3o coradas, que s\u00e3o t\u00edpicas destas les\u00f5es(setas).<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"419\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2446_1442751971.jpg?itok=CTjTdDkV\" width=\"518\" \/><\/a><figcaption>C\u00e9lulas mioepiteliais plasmocitoides s\u00e3o vistas frequentemente (A). O estroma \u00e9 t\u00edpico.(Giemsa)<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"488\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2447_1442751993.jpg?itok=sTJuDMXQ\" width=\"650\" \/><\/a><figcaption>C\u00e9lulas mioepiteliais plasmocitoides s\u00e3o vistas frequentemente (A). O estroma \u00e9 t\u00edpico.(Giemsa)<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"489\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2448_1442752026.jpg?itok=Z6gpPZ7G\" width=\"652\" \/><\/a><figcaption>Nestas imagens altamente celulares predomina o tipo alongado (fibroblastoide) de c\u00e9lula epitelial. O estroma mostra \u00e1reas suspeitas de calcifica\u00e7\u00e3o (A). (Giemsa)<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"490\" src=\"http:\/\/www.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2449_1442752056.jpg?itok=xdxhLGBS\" width=\"652\" \/><\/a><figcaption>Nestas imagens altamente celulares predomina o tipo alongado (fibroblastoide) de c\u00e9lula epitelial. O estroma mostra \u00e1reas suspeitas de calcifica\u00e7\u00e3o (A). (Giemsa)<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<\/figure>\n","protected":false},"excerpt":{"rendered":"<div data-object_id=\"6178\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/pt-pt\/wp-json\/wp\/v2\/course\/6178\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"6178\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"6178\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-6178\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nome de utilizador ou endere\u00e7o de email<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Senha<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Manter sess\u00e3o<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Iniciar sess\u00e3o\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/pt-pt\/wp-json\/wp\/v2\/course\/6178\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/pt-pt\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fpt-pt%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F6178%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>Este tumor \u00e9 tamb\u00e9m chamado de Adenoma pleom\u00f3rfico por ter uma estrutura composta. \u00c9 constitu\u00eddo por elementos mioepiteliais, em alguns casos podem se diferenciar em c\u00e9lulas escamosas queratinizadas ou estruturas glandulares, em conjunto com um componente do estroma. As c\u00e9lulas mioepiteliais podem ser plasmocitoides ou epitelioides. A forma\u00e7\u00e3o de cistos pode ocorrer. O estroma pode [&hellip;]<\/p>\n","protected":false},"featured_media":0,"parent":6177,"menu_order":0,"template":"","meta":[],"tags":[],"course_area":[122],"authors":[],"class_list":["post-6178","course","type-course","status-publish","hentry","course_area-cabeca-e-pescoco"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tumor misto - Eurocytology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.eurocytology.eu\/pt-pt\/course\/cabeca-e-pescoco-up-to-date-2015\/tumores-benignos-das-glandulas-salivares\/tumor-misto\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tumor misto - Eurocytology\" \/>\n<meta property=\"og:description\" content=\"Este tumor \u00e9 tamb\u00e9m chamado de Adenoma pleom\u00f3rfico por ter uma estrutura composta. \u00c9 constitu\u00eddo por elementos mioepiteliais, em alguns casos podem se diferenciar em c\u00e9lulas escamosas queratinizadas ou estruturas glandulares, em conjunto com um componente do estroma. As c\u00e9lulas mioepiteliais podem ser plasmocitoides ou epitelioides. A forma\u00e7\u00e3o de cistos pode ocorrer. 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