{"id":4392,"date":"2023-03-17T08:42:59","date_gmt":"2023-03-17T08:42:59","guid":{"rendered":"https:\/\/www.eurocytology.eu\/course\/4392-2\/"},"modified":"2023-04-17T08:46:39","modified_gmt":"2023-04-17T08:46:39","slug":"cervical-intraepithelial-neoplasia-cin","status":"publish","type":"course","link":"https:\/\/www.eurocytology.eu\/it\/course\/cervical-intraepithelial-neoplasia-cin\/","title":{"rendered":"Cervical Intraepithelial Neoplasia (CIN)"},"content":{"rendered":"<div data-object_id=\"4392\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/it\/wp-json\/wp\/v2\/course\/4392\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"4392\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"4392\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-4392\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nome utente o indirizzo email<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Password<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Ricordami<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Accedi\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/it\/wp-json\/wp\/v2\/course\/4392\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/it\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fit%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F4392%2F\">Register<\/a><\/p><\/div><\/div><\/div><h2>Caratteristiche citologiche e morfologiche della CIN<\/h2>\n<ul>\n<li>In tutti i casi di CIN, il normale epitelio della cervice \u00e8 sostituito da cellule epiteliali atipiche che mostrano vari gradi di differenziazione.<\/li>\n<li>Cellule neoplastiche o paraneoplastiche indifferenziate di aspetto basaloide o parabasaloide possono occupare l&#8217;intero spessore dell&#8217; epitelio (CIN3) o possono differenziarsi man mano procedono verso la superficie (CIN1,CIN2).<\/li>\n<li>I nuclei delle cellule indifferenziate sono grandi, irregolari, con variazione di forma e volume. Il contenuto in cromatina \u00e8 aumentato e irregolare nella sua struttura e il rapporto nucleo\/citoplasma \u00e8 aumentato.<\/li>\n<li>La quantit\u00e0 di citoplasma aumenta quando la cellule neoplastica si differenzia. Irregolarit\u00e0 nucleare, pleomorfismo ed anisonucleosi persistono per\u00f2 anche quando diminuisce la taglia nucleare.<\/li>\n<li>L&#8217;attivit\u00e0 mitotica non \u00e8 pi\u00f9 confinata allo strato basale dell&#8217;epitelio e mitosi atipiche possono essere viste ad ogni livello.<\/li>\n<li>E&#8217; poi frequente ritrovare foci di CIN1,CIN2 e CIN3 anche nella stessa cervice.<\/li>\n<\/ul>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img fetchpriority=\"high\" decoding=\"async\" alt=\"\" height=\"497\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img1a.jpg?itok=d97ddJd7\" width=\"361\" \/><\/a><figcaption><strong>CIN 1 (mild dysplasia):<\/strong> Note undifferentiated cells occupy lower third of the epithelium after which they start to differentiate so that the epithelial cells in the upper two thirds appear to have more cytoplasm and smaller (but abnormal) nuclei. Mitoses are rare.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"570\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img1b.jpg?itok=aSO7UnPF\" width=\"760\" \/><\/a><figcaption><strong>CIN&nbsp;2 (Moderate dysplasia):<\/strong> Note undifferentiated cells occupy two thirds of the epithelium after which they start to differentiate so that the epithelial cells in the upper two thirds appear to have more cytoplasm and smaller (but abnormal) nuclei. Mitoses are confined to the lower two thirds of the epithelium<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"570\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img1c.jpg?itok=Kc4lhXqh\" width=\"423\" \/><\/a><figcaption><strong>CIN 3 (carcinoma&nbsp;in situ):<\/strong>&nbsp;Undifferentiated neoplastic cells occupy the full thickness of the epithelium. Mitoses including abnormal mitoses can be seen throughout. Note that intraepithelial cancers the basement membrane is in tact and the stroma is not invaded by tumour cells.<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>Le cellule atipiche ritrovate nello striscio derivano dalla superficie dei focolai di CIN. Le cellule atipiche possono essere singole in lembi o in foglietti. Possono essere riconosciute rispetto alle cellule normali per le seguenti caratteristiche:<\/p>\n<blockquote>\n<p><strong>Le caratteristiche morfologiche delle cellule presenti nei foci di neoplasia intraepiteliale cervicale presenti in uno striscio cervicale sono:<\/strong><\/p>\n<ol>\n<li class=\"style50 style33 style63\">Irregolare ingrandimento nucleare che porta ad un aumento del rapporto nucleo\/citoplasma.<\/li>\n<li class=\"style33 style50\">Variazione nella forma e nel volume nucleare.<\/li>\n<li class=\"style33 style50\">Irregolarti\u00e0 nel profilo della membrana nucleare.<\/li>\n<li class=\"style33 style50\">Ipercromasia del nucleo e pattern atipico della cromatina<\/li>\n<li class=\"style33 style50\">Nuclei grandi, irregolari ed a volte multipli (non presenti in CIN1)<\/li>\n<li class=\"style33 style50\">Il grado della CIN (CIN 1, 2 o 3) pu\u00f2 essere dedotto dal grado di ingrandimento nucleare e dall&#8217;alterazione del rapporto nucleo\/citoplasma.<\/li>\n<\/ol>\n<\/blockquote>\n<p>Le tre Tavole ingrandibili sottostanti descrivono e illustrano con serie di diapositive le caratteristiche citologiche e i differenti gradi dellaCIN<\/p>\n<h3>Cytological diagnosis of CIN1 (encompassing LSIL and mild dysplasia)<\/h3>\n<h3><strong style=\"font-size: 15px; line-height: 1.72222;\">The Bethesda System definition of CIN 1 (LSIL, mild dysplasia)<\/strong><\/h3>\n<ul>\n<li>Nuclear enlargement is three or more times that of a normal intermediate cell nucleus*<\/li>\n<li>Nuclear\/cytoplasmic ratio may or may not be altered as cytoplasm is usually&nbsp; abundant and may be keratinised. Cell borders are usually distinct<\/li>\n<li>Moderate variation in nuclear size and shape<\/li>\n<li>Binucleation or multinucleation are not uncommon<\/li>\n<li>Hyperchromasia with uniformly distributed chromatin. The chromatin may appear degenerated or smudged if associated with HPV changes<\/li>\n<li>Nucleoli are rare or inconspicuous<\/li>\n<li>Nuclear membrane may or may not be distinct<\/li>\n<li>Cells with a well-defined, optically empty perinuclear halo and peripheral dense cytoplasm (the so called koilocytotic atypia) must also show the above described nuclear abnormalities to be classified as&nbsp;CIN 1 (LSIL).<\/li>\n<\/ul>\n<p>*The WHO cytological definition of CIN 1 requires that the nucleus occupies less than one half the area of the cell.<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"815\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img2a.jpg?itok=sqQ0zCTK\" width=\"744\" \/><\/a><figcaption>CIN 1 (LSIL) Note slight nuclear enlargement and abundant cytoplasm. Nuclei vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"770\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img2b.jpg?itok=vpqh6Vnu\" width=\"1024\" \/><\/a><figcaption>CIN 1 (LSIL) Slight nuclear enlargement and abundant cytoplasm. Nuclei vary in size and shape.&nbsp;Note highly keratinised cytoplasm suggestive of HPV infection although koilocytes are not shown in this field.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"726\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img2c.jpg?itok=1DazLEQM\" width=\"1024\" \/><\/a><figcaption>CIN 1 (LSIL) Note slight nuclear enlargement and abundant cytoplasm. Nuclei vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"722\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img2d.jpg?itok=jwig_yCX\" width=\"1025\" \/><\/a><figcaption>CIN 1 (LSIL) Slight nuclear enlargement and abundant cytoplasm. Nuclei vary in size and shape.&nbsp;Note koilocytotic atypia<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"831\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img2e.jpg?itok=oy2FVhM8\" width=\"1039\" \/><\/a><figcaption>CIN 1 (LSIL) Note slight nuclear enlargement and abundant cytoplasm. Nuclei vary in size and shape.<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h3>The Bethesda System definition of CIN 2 (HSIL)<\/h3>\n<p><strong>The Bethesda System definition of CIN 2 (HSIL)<\/strong><\/p>\n<ul>\n<li>Cells occur singly or grouped in sheets or in syncytial-like clusters with crowded nuclei<\/li>\n<li>Cells generally have&nbsp; delicate or dense cytoplasm; occasionally the cytoplasm is heavily keratinised<\/li>\n<li>Nuclear enlargement is three or more times greater than that of normal intermediate cell nuclei*<\/li>\n<li>The cytoplasmic area may be decreased. For this reason, in a cell with very high nuclear\/cytoplasmic ratio, the dimension of the nucleus can be smaller than in LSIL<\/li>\n<li>Nuclear borders are irregular<\/li>\n<li>Anisonucleosis is prominent<\/li>\n<li>Hyperchromasia of nuclei is present and chromatin granular &amp; evenly distributed (fine or coarse)<\/li>\n<li>Overall cell size may be&nbsp; smaller than in LSIL<\/li>\n<\/ul>\n<p>*The WHO cytological definition of CIN 1 requires that the nucleus occupies between one half and two thirds the area of the cell.<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"690\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img3a.jpg?itok=n11GUU46\" width=\"1193\" \/><\/a><figcaption>CIN 2 (HSIL) The nucleus occupies more then one half the area of the cell and are hyperchromatic and vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"733\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img3b.jpg?itok=HnUYtOVV\" width=\"1026\" \/><\/a><figcaption>CIN 2 (HSIL) The nucleus occupies more then one half the area of the cell and are hyperchromatic and vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"768\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img3c.jpg?itok=d3d9YLco\" width=\"1039\" \/><\/a><figcaption>CIN 2 (HSIL) The nucleus occupies more then one half the area of the cell and are hyperchromatic and vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"721\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img3d.jpg?itok=a6mlcnpa\" width=\"1282\" \/><\/a><figcaption>CIN 2 (HSIL) The nucleus occupies more then one half the area of the cell and are hyperchromatic and vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"815\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img3e.jpg?itok=AFAwQC4M\" width=\"928\" \/><\/a><figcaption>CIN 2 (HSIL) The nucleus occupies more then one half the area of the cell and are hyperchromatic and vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"417\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img3f.jpg?itok=qyCxwjOi\" width=\"550\" \/><\/a><figcaption>CIN 2 (HSIL) The nucleus occupies more then one half the area of the cell and are hyperchromatic and vary in size and shape.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"742\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img3g.jpg?itok=EBE-ugCv\" width=\"928\" \/><\/a><figcaption>CIN 2 (HSIL) The nucleus occupies more then one half the area of the cell and are hyperchromatic and vary in size and shape.<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h3>Cytological diagnosis of CIN3 (encompassing HSIL, severe dysplasia and carcinoma&nbsp;in situ)<\/h3>\n<p><strong>The Bethesda System definition CIN 3 (HSIL)<\/strong><\/p>\n<ul>\n<li>Cells occur singly or grouped in sheets or in syncytial-like clusters<\/li>\n<li>Abnormal nuclei&nbsp; generally found in cells with \u201cimmature\u201d, delicate or dense&nbsp; cytoplasm; occasionally the cytoplasm is heavily keratinised<\/li>\n<li>Nuclear enlargement is three or more times the area of normal intermediate nuclei*<\/li>\n<li>The cytoplasmic area is decreased. For this reason, in a cell with very high nuclear\/cytoplasmic ratio, the dimension of the nucleus can be smaller than in LSIL<\/li>\n<li>Overall cell size is often ksmaller than in LSIL<\/li>\n<li>Nuclei are hyperchromatic usually&nbsp; with granular coarse chromatin<\/li>\n<li>Nuclear borders are irregular and&nbsp; anisonucleosis is a prominent feature<\/li>\n<li>When the abnormal cells occur in sheets ,the nuclei are crowded and overlapping and mitotic figures may be seen<\/li>\n<\/ul>\n<p><strong>*The WHO cytological definition of CIN 3 requires that the nucleus occupies more than two thirds of the area of the cell.<\/strong><\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"530\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img4a.jpg?itok=3seXoVIU\" width=\"834\" \/><\/a><figcaption>CIN 3 (HSIL) The nucleus occupies more then two thirds of the area of the cell. Note variation in nuclear size and shape and increased and irregular chromatin distribution. There is a loss of polarity in this cluster and cells are overlapping.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"502\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img4b.jpg?itok=myyONBTl\" width=\"644\" \/><\/a><figcaption>CIN 3 (HSIL) The nucleus occupies more then two thirds of the area of the cell. Note variation in nuclear size and shape and increased and irregular chromatin distribution.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"322\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img4c.jpg?itok=4corI4Nf\" width=\"402\" \/><\/a><figcaption>CIN 3 (HSIL) The nucleus occupies more then two thirds of the area of the cell. Note variation in nuclear size and shape and increased and irregular chromatin distribution.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"771\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img4d.jpg?itok=qB44Sz2O\" width=\"1028\" \/><\/a><figcaption>CIN 3 (HSIL) The nuclei occupy more then two thirds of the area of the cell. Note variation in nuclear size and shape and increased and irregular chromatin distribution in this dense cluster of cells.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"770\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img4f.jpg?itok=I3fx5b7v\" width=\"1026\" \/><\/a><figcaption>CIN 3 (HSIL) Two very large bare hyperchromatic nuclei are seen in this smear. They vary in size and shape and suggest the presence of a focus of CIN 3<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<div data-object_id=\"4392\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/it\/wp-json\/wp\/v2\/course\/4392\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"4392\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"4392\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-4392\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nome utente o indirizzo email<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Password<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Ricordami<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Accedi\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/it\/wp-json\/wp\/v2\/course\/4392\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/it\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fit%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F4392%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>Caratteristiche citologiche e morfologiche della CIN In tutti i casi di CIN, il normale epitelio della cervice \u00e8 sostituito da cellule epiteliali atipiche che mostrano vari gradi di differenziazione. Cellule neoplastiche o paraneoplastiche indifferenziate di aspetto basaloide o parabasaloide possono occupare l&#8217;intero spessore dell&#8217; epitelio (CIN3) o possono differenziarsi man mano procedono verso la superficie [&hellip;]<\/p>\n","protected":false},"featured_media":0,"parent":0,"menu_order":0,"template":"","meta":[],"tags":[],"course_area":[],"authors":[],"class_list":["post-4392","course","type-course","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cervical Intraepithelial Neoplasia (CIN) - Eurocytology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.eurocytology.eu\/it\/course\/cervical-intraepithelial-neoplasia-cin\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cervical Intraepithelial Neoplasia (CIN) - Eurocytology\" \/>\n<meta property=\"og:description\" content=\"Caratteristiche citologiche e morfologiche della CIN In tutti i casi di CIN, il normale epitelio della cervice \u00e8 sostituito da cellule epiteliali atipiche che mostrano vari gradi di differenziazione. Cellule neoplastiche o paraneoplastiche indifferenziate di aspetto basaloide o parabasaloide possono occupare l&#8217;intero spessore dell&#8217; epitelio (CIN3) o possono differenziarsi man mano procedono verso la superficie [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.eurocytology.eu\/it\/course\/cervical-intraepithelial-neoplasia-cin\/\" \/>\n<meta property=\"og:site_name\" content=\"Eurocytology\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-17T08:46:39+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/mod6img1a.jpg?itok=d97ddJd7\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.eurocytology.eu\/it\/course\/cervical-intraepithelial-neoplasia-cin\/\",\"url\":\"https:\/\/www.eurocytology.eu\/it\/course\/cervical-intraepithelial-neoplasia-cin\/\",\"name\":\"Cervical Intraepithelial Neoplasia (CIN) - 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