{"id":6161,"date":"2023-03-17T08:43:03","date_gmt":"2023-03-17T08:43:03","guid":{"rendered":"https:\/\/www.eurocytology.eu\/course\/bronchioloalveolar-carcinoma\/"},"modified":"2023-04-20T08:18:48","modified_gmt":"2023-04-20T08:18:48","slug":"bronchioloalveolar-carcinoma","status":"publish","type":"course","link":"https:\/\/www.eurocytology.eu\/es\/course\/bronchioloalveolar-carcinoma\/","title":{"rendered":"Bronchioloalveolar carcinoma"},"content":{"rendered":"<div data-object_id=\"6161\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/6161\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"6161\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"6161\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-6161\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nombre de usuario o correo electr\u00f3nico<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Contrase\u00f1a<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Recu\u00e9rdame<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Acceder\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/6161\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/es\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fes%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F6161%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>It is considered as a variant of pulmonary adenocarcinoma, accounting for about 5% of lung cancers. It is often multifocal, grossly appearing as a pneumonic consolidation. A characteristic feature is its growth along alveolar septa (lepidic growth pattern), without destroying the underlying alveolar architecture. Two subtypes are recognized: the cuboidal non-mucinous type and the mucinous type.<\/p>\n<h4>Cytologic diagnostic features (sputum and bronchial washing)<\/h4>\n<ul>\n<li>Small glandular clusters<\/li>\n<li>Regular small cells with large cytoplasm<\/li>\n<li>Nuclear hyperchromasia or vescicular nuclei with prominent nucleoli<\/li>\n<li>Clean background<\/li>\n<\/ul>\n<h4>Cytologic diagnostic features (FNA and bronchial brushing)<\/h4>\n<ul>\n<li>Monotonous cell population<\/li>\n<li>Arrangements in cellular balls, sheets and papillae<\/li>\n<li>Clean background<\/li>\n<\/ul>\n<p>The bronchioloalveolar carcinoma can be hardly distinguished from classic adenocarcinoma on cytologic preparations. Some cases may strictly resemble a papillary thyroid carcinoma, because of the presence of psammoma bodies, occasional nuclear grooves and pseudoinclusions, optically clear nuclei. Clinical history is helpful to exclude a metastasis.<\/p>\n<h4>Immunocytochemistry<\/h4>\n<ul>\n<li>Cytokeratin 7 +<\/li>\n<li>Cytokeratin 5 \u2013<\/li>\n<li>Cytokeratin 20 \u2013<\/li>\n<li>Neuroendocrine markers +-<\/li>\n<li>TTF-1 +<\/li>\n<\/ul>\n<h3>Bronchioloalveolar carcinoma:<\/h3>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture1_33.jpg?itok=4wa7Z06K\" width=\"220\" \/><\/a><figcaption>Bronchioloalveolar carcinoma. Somewhat cohesive fragment of tumor with tightly packed, minimally pleomorphic nuclei. Also note a few cytoplasmic mucin vacuoles.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture2_29.jpg?itok=nemy7bGQ\" width=\"220\" \/><\/a><figcaption>Bronchioloalveolar carcinoma. Loosely cohesive tissue fragments with hyperchromatic crowded nuclei mixed with numerous alveolar macrophages.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture3_25.jpg?itok=gAu3bnbB\" width=\"220\" \/><\/a><figcaption>Bronchioloalveolar carcinoma. Neoplastic epithelium appearing as a cohesive three-dimensional ball-like structure. Note the monotonous appearance of the neoplastic cells.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture4_16.jpg?itok=ePuLNWdb\" width=\"220\" \/><\/a><figcaption>Bronchioloalveolar carcinoma. Small tissue fragment showing peripherally protruding nuclei (knobby outline) giving the cells a so-called &#8220;hobnail&#8221; appearance. Note also a benign multinucleated histiocyte on the left.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture5_14.jpg?itok=LXN7t7jg\" width=\"220\" \/><\/a><figcaption>Bronchioloalveolar carcinoma. A loosely cohesive tissue fragment with monotonous nuclei, vesicular chromatin, and small but prominent nucleoli. Note the deceptive benign appearance of the fragment.<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"144\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture8_7.jpg?itok=7I5Rq0t6\" width=\"220\" \/><\/a><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"167\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture9_4.jpg?itok=8Ebt3zuE\" width=\"220\" \/><\/a><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"153\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture10_7.jpg?itok=A1JlcUG8\" width=\"220\" \/><\/a><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"147\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture11_4.jpg?itok=p-UpEaiy\" width=\"220\" \/><\/a><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"160\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture12_3.jpg?itok=TyLWBcjz\" width=\"220\" \/><\/a><\/figure>\n<h3>FNA:<\/h3>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture13_4.jpg?itok=rC6SZHH3\" width=\"220\" \/><\/a><figcaption>FNA of BAC &#8211; TTF-1<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture14_1.jpg?itok=9lhj7xC9\" width=\"220\" \/><\/a><figcaption>FNA of BAC &#8211; TTF-1<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"165\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture15_2.jpg?itok=8Ty8Lnn2\" width=\"220\" \/><\/a><figcaption>FNA of BAC &#8211; TTF-1<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<div data-object_id=\"6161\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/6161\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"6161\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"6161\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-6161\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nombre de usuario o correo electr\u00f3nico<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Contrase\u00f1a<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Recu\u00e9rdame<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Acceder\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/6161\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/es\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fes%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F6161%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>It is considered as a variant of pulmonary adenocarcinoma, accounting for about 5% of lung cancers. It is often multifocal, grossly appearing as a pneumonic consolidation. A characteristic feature is its growth along alveolar septa (lepidic growth pattern), without destroying the underlying alveolar architecture. Two subtypes are recognized: the cuboidal non-mucinous type and the mucinous [&hellip;]<\/p>\n","protected":false},"featured_media":0,"parent":0,"menu_order":0,"template":"","meta":[],"tags":[],"course_area":[],"authors":[],"class_list":["post-6161","course","type-course","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bronchioloalveolar carcinoma - Eurocytology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.eurocytology.eu\/es\/course\/bronchioloalveolar-carcinoma\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bronchioloalveolar carcinoma - Eurocytology\" \/>\n<meta property=\"og:description\" content=\"It is considered as a variant of pulmonary adenocarcinoma, accounting for about 5% of lung cancers. 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