{"id":5967,"date":"2023-03-17T08:42:44","date_gmt":"2023-03-17T08:42:44","guid":{"rendered":"https:\/\/www.eurocytology.eu\/course\/tiroiditis-linfocitica-cronica-hashimoto\/"},"modified":"2023-04-26T09:24:26","modified_gmt":"2023-04-26T09:24:26","slug":"tiroiditis-linfocitica-cronica-hashimoto","status":"publish","type":"course","link":"https:\/\/www.eurocytology.eu\/es\/course\/citologia-de-tiroides\/condiciones-benignas\/tiroiditis-linfocitica-cronica-hashimoto\/","title":{"rendered":"Tiroiditis linfoc\u00edtica cr\u00f3nica (Hashimoto)"},"content":{"rendered":"<div data-object_id=\"5967\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/5967\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"5967\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"5967\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-5967\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nombre de usuario o correo electr\u00f3nico<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Contrase\u00f1a<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Recu\u00e9rdame<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Acceder\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/5967\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/es\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fes%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F5967%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>Esta es una enfermedad autoinmune en la cual el par\u00e9nquima es virtualmente reemplazado por un infiltrado linfoide con centros germinales, algunas veces con una marcada fibrosis en casos de enfermedad de larga duraci\u00f3n. Varios autoanticuerpos han sido identificados en pacientes afectados, tales como anticuerpos contra los ant\u00edgenos microsomales tiroideos y contra receptores de TSH.<\/p>\n<p>La gl\u00e1ndula est\u00e1 usualmente aumentada de tama\u00f1o, no es dolorosa, y puede tener o no tener n\u00f3dulos. Algunos pacientes pueden ser hipertiroideos o eutiroideos al principio, pero m\u00e1s tarde la mayor\u00eda se hacen hipotiroideos.<\/p>\n<h3>Caracter\u00edsticas citol\u00f3gicas diagn\u00f3sticas<\/h3>\n<ul>\n<li>Poblaci\u00f3n mixta de linfocitos<\/li>\n<li>Macr\u00f3fagos con cuerpos tingibles<\/li>\n<li>Agregados linfohistioc\u00edticos<\/li>\n<li>C\u00e9lulas de H\u00fcrtle<\/li>\n<\/ul>\n<p>Los aspirados son usualmente celulares, compuestos predominantemente por linfocitos (peque\u00f1os linfocitos, centroblastos y centrocitos) que pueden ser intraepiteliales y c\u00e9lulas plam\u00e1ticas. Tambi\u00e9n se encuentran presentes agregados &nbsp;linfohistiocitarios y macr\u00f3fagos con cuerpos tingibles. Pueden verse grupos ocasionales de c\u00e9lulas tiroideas, usualmente con cambios degenerativos y morfolog\u00eda oncoc\u00edtica: estos tienen abundante citoplasma eosin\u00f3filo granular y n\u00facleo aumentado de tama\u00f1o (Metaplasma de c\u00e9lula Hurtle). Pueden tambi\u00e9n estar presentes c\u00e9lulas gigantes multinucleadas. El coloide es usualmente escaso o ausente.<\/p>\n<p>El diagn\u00f3stico citol\u00f3gico es usualmente sencillo y necesita confirmaci\u00f3n mediante la identificaci\u00f3n serol\u00f3gica de autoanticuerpos.<\/p>\n<h3>Diagn\u00f3stico diferencial<\/h3>\n<ul>\n<li>Linfoma No Hodgkin<\/li>\n<li>Neoplasia de c\u00e9lulas Hurtle<\/li>\n<\/ul>\n<p>La prevalencia de linfoma es mayor en pacientes con tiroiditis de Hashimoto; el linfoma usualmente consiste en una poblaci\u00f3n uniforme de c\u00e9lulas linfoides at\u00edpicas. Los tumores de c\u00e9lula Hurtle deben difenciarse de los n\u00f3dulos celulares de Hurtle hiperpl\u00e1sicos, que pueden ocurrir en la tiroiditis de Hashimoto; las c\u00e9lulas de tumores usualmente tienen nucleolo prominente y son menos cohesivas que las c\u00e9lulas de tiroiditis.<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img fetchpriority=\"high\" decoding=\"async\" alt=\"\" height=\"469\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture1_1.jpg\" width=\"625\" \/><\/a><figcaption>A low power view of Hashimoto&#8217;s thyroiditis. Very cellular background with numerous lymphocytes and a few follicular groups.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"711\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/picture2_0.jpg\" width=\"949\" \/><\/a><figcaption>Histiocytes surrounded by lymphocytes. A group of histiocytes in a background of a polymorphic lymphoid population and plasmacells.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"325\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture3_1.jpg\" width=\"433\" \/><\/a><figcaption>A follicle surrounded by a polymorphic lymphoid infiltration. A follicle containing colloid surrounded by a polymorphic lymphoid population. Note the streaks of nuclear material from the more fragile lymphocytes. When present within better preserved epithelial cells this is suggestive of intraepithelial lymphocytic infiltration.<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"325\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture4_46.jpg?itok=brhTIMOW\" width=\"433\" \/><\/a><figcaption>\n<p>Follicular cells surrounded by lymphocytes.<\/p>\n<p>A group of epithelial cells surrounded and partially infiltrated by lymphocytes. Note the variability of nuclear size and granular chromatin. Often individual cells may cause problem at high power. When clear cut nuclear pseudoinclusions are seen the suspicion of a papillary carcinoma in a background of chronic thyroiditis should be raised.<\/p>\n<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"325\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/Picture5_38.jpg?itok=DPJZ1ilY\" width=\"433\" \/><\/a><figcaption>\n<p>A follicle infiltrated by lymphocytes.<\/p>\n<p>A group of slightly crowded epithelial cells in a follicular arrangement, infiltrated by lymphocytes. Note the nuclear streaking.<\/p>\n<\/figcaption><\/figure>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" height=\"325\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/picture6.jpg\" width=\"433\" \/><\/a><figcaption>Lymphocytes, plasmacells admixed with poorly preserved thyroid epithelial cells. A polymorphic population of lymphocytes and plasmacells admixed (lower left side) with epithelial cells which exhibit a denser cytoplasm, reminiscent of H\u00fcrthle cell metaplasia.<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<div data-object_id=\"5967\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/5967\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"5967\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"5967\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-5967\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Nombre de usuario o correo electr\u00f3nico<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Contrase\u00f1a<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Recu\u00e9rdame<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Acceder\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/es\/wp-json\/wp\/v2\/course\/5967\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/es\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fes%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F5967%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>Esta es una enfermedad autoinmune en la cual el par\u00e9nquima es virtualmente reemplazado por un infiltrado linfoide con centros germinales, algunas veces con una marcada fibrosis en casos de enfermedad de larga duraci\u00f3n. Varios autoanticuerpos han sido identificados en pacientes afectados, tales como anticuerpos contra los ant\u00edgenos microsomales tiroideos y contra receptores de TSH. La [&hellip;]<\/p>\n","protected":false},"featured_media":0,"parent":5964,"menu_order":2,"template":"","meta":[],"tags":[],"course_area":[115],"authors":[],"class_list":["post-5967","course","type-course","status-publish","hentry","course_area-citologia-de-tiroides"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tiroiditis linfoc\u00edtica cr\u00f3nica (Hashimoto) - Eurocytology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.eurocytology.eu\/es\/course\/citologia-de-tiroides\/condiciones-benignas\/tiroiditis-linfocitica-cronica-hashimoto\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tiroiditis linfoc\u00edtica cr\u00f3nica (Hashimoto) - Eurocytology\" \/>\n<meta property=\"og:description\" content=\"Esta es una enfermedad autoinmune en la cual el par\u00e9nquima es virtualmente reemplazado por un infiltrado linfoide con centros germinales, algunas veces con una marcada fibrosis en casos de enfermedad de larga duraci\u00f3n. Varios autoanticuerpos han sido identificados en pacientes afectados, tales como anticuerpos contra los ant\u00edgenos microsomales tiroideos y contra receptores de TSH. 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