It is a large B-cell lymphoma which presents as a pleural, pericardial or peritoneal effusion. There is no associated mass lesion or lymphadenopaty. Most cases arise in the setting of HIV infection. The prognosis is poor.
Cytologic diagnostic features
Dispersed large cells
Round or irregular nuclei, prominent nucleoli
Abundant basophilic cytoplasm (Romanowsky stain)
Flow Cytometry on a fresh sample confirms the morphological findings
High grade lymphomatous effusionCD20CD3Ki-67
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