Colloid is usually abundant, appearing as amorphous blobs or as a thin translucent film with bubbles and linear cracks.
Some benign follicular lesions are hypercellular and even focal cytologic atypia may occur. Occasional large, spindle-shaped cells may be present, representing either reactive stromal elements or altered follicular cells lining areas of cystic degeneration. Focal Hürthle cell change may also occur. If microfollicles are few and atypia is focal, a diagnosis of cytologically benign nodule should be made, even if the specimen is cellular. Patients with this diagnosis have to be followed up at an appropriate interval.
A microfollicular pattern:
It is a benign neoplasm, presenting as a single nodule, usually not greater than 3 cm in diameter. Some of them can produce thyroid hormones and consequently cause hyperthyroidism (functioning or 'hot' adenomas). The hystologic pattern may vary: macrofollicular (composed of large follicles filled with colloid), microfollicular (with smaller follicles), trabecular (with follicular cells arranged in ribbons).
Classification (no prognostic significance):
signet ring cell
uniformity of the architecture
comparable areas in adjacent gland
different from surrounding gland
no compression of surrounding gland
compression of surrounding gland
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