Mammary like Secretory carcinoma of the Salivary Gland
This is a recently described entity which seems to be significantly more important and common as we have thought. The first description comes from A. Skalova: It is a mimic of acinic cell carcinoma and adenocarcinoma of clear cell type, usually the granules of the acinic cell carcinoma cells is missing. The until now described cases showed adenocarcinoma like appearance: true tissue fragments, sometimes even papillary formations, dissociated clear cells and vacuolated cell may also be present. The final diagnosis is based upon the presence molecular change: the ETV6-NTRK3 fusion gene. The molecular analysis theoretically must be doable also on cytology material before the surgery. MASC is immunoreactive for CK7. CK18, S-100 protein, vimentin. The classical myoepithelial markers may be slightly positive, present only in a few cells, or absolutely absent. The tumor is negative of ER and PR receptor.
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