Μικροκυτταρικό καρκίνωμα

???????????? ??? ???????? ??????? ?? 20-25% ??? ?????????? ???????? ??? ????????. ?? ???????????? ???????? ????? ?????????. ? ????? ??????????? ????? ??????????? ??? ? ???????? ????? ?????

?? ?????????????? ????????? ??????????? ?????? ??? ?????, ????????? ???? ??????????? ??????? ?? ???????? ?????????????. ?????????????? ?????????? ????????? ? ???????, ? ??????? ??????? ????????, ??? ? ?????? ?????????? ??????? ??? ???????. ?? ??????? ??? ???????? ????? ????? ?????????? ?? ??????????? ????????????? ??? ?????? ??????.

????????????? ??????????? ?????????????? (?????? ??? ???????? ???????)

  • ????????? ?????? ??? ????? ????????? ??????? ?? ?????? ?????? (??? ????? ?? ??????? ??? ?????????????, ?????? ??????????)
  • ???????? ?????????????, ???????? ???????? (??? ??????), ?????????????? ???????, ??? ???? ?? ?????? ??????? ?????????? ??molding??.
  • ????? ?????? ??????????, ??????????? ???????
  • ???????????? ??????????
  • ??????????? ????????? ???????     

????????????? ??????????? ?????????????? (FNA ??? ??????????? ??????)

  • ???????? ??????????? ??? ?????????? ??????? ?????????? ?? ?? ?????? (???? ? ???????????).
  • ???????? ??molding?? ??? ???????????
  • ??????? ??????? ?? ????? ?????? ?????????? ? ??????????.
  • ?????? ???????????? ???????, ?? ????? ?????? ??????????
  • ????? ??????????? ??????? ??? ??????? (crush artefact).

????????? ????????

  • ?????????? ????????? ????????
  • ????????????
  • ?????????? ????????
  • ????????????
  • ??-?????????????? ?????????
  • ??????? Ewing
  • ?????????????

?? ??????? ??? ??????????? ??? ????????? ???????? ?????????? ??? ????  ??molding?? , ???? ????? ????????? ??? ?? ?????????? ?????? ??? ???? ??? ??????????????? ????????????. ?? ????????? ???????, ??? ??????????? ??? ??? ?????????? ????????? ? ??? ???????, ?????? ?? ????????? ?????????? ??? ????????? ??? ??????? ??????????????? ????????????, ???? ???? ??????? ??? ??????????? ?????? ??? ???? ????? ??????? ????? ????????? ??????? ??? ?? ????????? ???????. ????? ????????????? ?????? ??? ????????????? ???????? ??molding??, ??????? ??? ???????? ?????????????, ??? ? ??? ??? ?????????? ????? ??????????? ????????. ? ???????? ?????? ??????????????? ???????????? ??? ???? ?????? ????????????? ????? ????? ??????????? ???????. ??????? ?? ?????????????? ??????????? ????? ???????? ?????????????, ??????????? ???????? ??molding?? ??? ????????????? ?????? ??????????. ?? ?????????????? ????????? ?????????? ?? ????????????????? ??? ?? ????? ??????????????? ??-?????????????? ?????????, ???? ?? ???????? ??? ?? ??????????????. ? ????????????? ??? ??? ??????????, ?? ??????????? ??????? ??? ?? ?????? ???????? ??molding?? ????? ????????? ?????????????? ???? ???????? ??? ??????????????? ????????????.

Immunocytochemistry

  • Neuroendocrine markers + (Chromogranin A, CD56, NSE, Synaptophysin)
  • Cytokeratin 7 +
  • Cytokeratin 5 –
  • Cytokeratin 20 –
  • TTF-1 + 
Sputum
Sputum
Brush
Wash
FNA
FNA
FNA
Small cell carcinoma. Extensive cellular necrosis with a single cluster of malignant round to ovoid cells appearing as naked nuclei with fine powdery chromatin and lack of nucleoli. Note the prominent nuclear molding.
Small cell carcinoma. Note the small to intermediate cell size, naked appearance of the nuclei, fine powdery chromatin, and a few karyorrhectic nuclei. Focal nuclear molding. 
Small cell carcinoma. Malignant cells with nuclear molding, relatively small cell size, naked nuclei, and fine powdery chromatin. 
Small cell carcinoma. Malignant cells with prominent nuclear molding, lack of cytoplasm ("naked nuclei"), relatively small cell size, fine powdery chromatin, and lack of nucleoli.
Small cell versus lymphocytes.
Reserve cell hyperplasia.

FNA:

FNA
FNA
FNA
Histology

Bronchial brush:

Bronchial brush
Bronchial brush
Bronchial brush

 

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