{"id":5108,"date":"2023-03-17T08:43:05","date_gmt":"2023-03-17T08:43:05","guid":{"rendered":"https:\/\/www.eurocytology.eu\/course\/5-die-grundlagen-des-screenings-und-die-messung-der-treffsicherheit\/"},"modified":"2023-04-26T07:39:11","modified_gmt":"2023-04-26T07:39:11","slug":"5-die-grundlagen-des-screenings-und-die-messung-der-treffsicherheit","status":"publish","type":"course","link":"https:\/\/www.eurocytology.eu\/de\/course\/zervixzytologie-auf-dem-laufenden-2016\/5-die-grundlagen-des-screenings-und-die-messung-der-treffsicherheit\/","title":{"rendered":"5. Die Grundlagen des Screenings und die Messung der Treffsicherheit"},"content":{"rendered":"<div data-object_id=\"5108\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/de\/wp-json\/wp\/v2\/course\/5108\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"5108\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"5108\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-5108\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Benutzername oder E-Mail-Adresse<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Passwort<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Angemeldet bleiben<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Anmelden\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/de\/wp-json\/wp\/v2\/course\/5108\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/de\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fde%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F5108%2F\">Register<\/a><\/p><\/div><\/div><\/div><h3>Grundlagen des Screenings<\/h3>\n<p>Wenngleich es sicher diverse \u00e4hnliche Autorschaften gab, entsprechen die Kriterien f\u00fcr das zytologische Screening auch heute noch im Wesentlichen jenen die von Wilson &amp; Jungner aufgestellt wurden (1968) (Abbildung 5.1).&nbsp;&nbsp;<\/p>\n<p>Diese Grundlagen wurden k\u00fcrzlich von Andermann <em>et al<\/em>. (2008) um die Tatsache revidiert, dass HPV-Hochrisikost\u00e4mme als notwendige Ursache f\u00fcr die Entstehung von Zervixkarzinomen und seiner Vorstufen fungieren (Walboomers <em>et al.<\/em> 1999).&nbsp;<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img fetchpriority=\"high\" decoding=\"async\" alt=\"\" height=\"263\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2226_1427369735.png?itok=iBwNscuw\" width=\"484\" \/><\/a><figcaption>Abbildung 5.1 zug\u00e4nglich unter&nbsp; http:\/\/www.who.int\/bulletin\/volumes\/86\/4\/07-050112\/en\/ [2]<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p><strong>Cervical screening has been instrumental in the prevention of a condition that was (and in the absence of screening is) \u2018an important health problem\u2019.&nbsp;<\/strong><\/p>\n<p><strong>\u2018Increasing knowledge about the natural history of the disease\u2019 has raised problems (management of reversible vs. progressive lesions) and provided alternative solutions (vaccination and HPV testing) that are in the process of integration with cytological screening.<\/strong><\/p>\n<p>Wilson &amp; Jungner erkannten die \u201cT\u00fccken des Screenings\u201d \u2013 im Besonderen im Hinblick darauf jenen Personen nicht zu schaden, die keine Behandlung ben\u00f6tigen. Ihr Diagramm (siehe unten &#8211; Abbildung 5.2) zeigt das Problem, n\u00e4mlich einen Zustand zu erkennen, der auf einer bimodalen (zweigipfeligen) H\u00e4ufigkeitsverteilung beruht &#8211; n\u00e4mlich der m\u00f6glichen Entwicklung von hochgradigen Karzinomvorstufen auf dem Boden einer unverh\u00e4ltnism\u00e4\u00dfig h\u00e4ufigeren Pr\u00e4valenz und vor allem reversiblen HPV Infektion.&nbsp;<\/p>\n<figure><a data-toggle=\"modal\" href=\"#modal-container-2\"><img decoding=\"async\" alt=\"\" height=\"534\" src=\"http:\/\/lnx.eurocytology.eu\/sites\/default\/files\/styles\/max\/public\/images\/2227_1427369848.png?itok=RXDdWzjF\" width=\"500\" \/><\/a><figcaption>Abbildung 5.2. Unimodale und bimodale Verteilung in einer Gesamtbev\u00f6lkerung (aus Wilson &amp; Jungner 1968)<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<div data-object_id=\"5108\" class=\"cbxwpbkmarkwrap cbxwpbkmarkwrap_guest cbxwpbkmarkwrap_user_cat cbxwpbkmarkwrap-course \"><a  data-redirect-url=\"https:\/\/www.eurocytology.eu\/de\/wp-json\/wp\/v2\/course\/5108\/\"  data-display-label=\"1\" data-show-count=\"1\" data-bookmark-label=\"Bookmark\"  data-bookmarked-label=\"Bookmarked\"  data-loggedin=\"0\" data-type=\"course\" data-object_id=\"5108\" class=\"cbxwpbkmarktrig  cbxwpbkmarktrig-button-addto\" title=\"Bookmark This\" href=\"#\"><span class=\"cbxwpbkmarktrig-label\" >Bookmark (<i class=\"cbxwpbkmarktrig-count\">0<\/i>)<\/span><\/a> <div  data-type=\"course\" data-object_id=\"5108\" class=\"cbxwpbkmarkguestwrap\" id=\"cbxwpbkmarkguestwrap-5108\"><div class=\"cbxwpbkmarkguest-message\"><a href=\"#\" class=\"cbxwpbkmarkguesttrig_close\"><\/a><h3 class=\"cbxwpbookmark-title cbxwpbookmark-title-login\">Please login to bookmark<\/h3><form name=\"loginform\" id=\"loginform\" action=\"https:\/\/www.eurocytology.eu\/wp-login.php\" method=\"post\"><p class=\"login-username\">\n\t\t\t\t<label for=\"user_login\">Benutzername oder E-Mail-Adresse<\/label>\n\t\t\t\t<input type=\"text\" name=\"log\" id=\"user_login\" autocomplete=\"username\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-password\">\n\t\t\t\t<label for=\"user_pass\">Passwort<\/label>\n\t\t\t\t<input type=\"password\" name=\"pwd\" id=\"user_pass\" autocomplete=\"current-password\" spellcheck=\"false\" class=\"input\" value=\"\" size=\"20\" \/>\n\t\t\t<\/p><p class=\"login-remember\"><label><input name=\"rememberme\" type=\"checkbox\" id=\"rememberme\" value=\"forever\" \/> Angemeldet bleiben<\/label><\/p><p class=\"login-submit\">\n\t\t\t\t<input type=\"submit\" name=\"wp-submit\" id=\"wp-submit\" class=\"button button-primary\" value=\"Anmelden\" \/>\n\t\t\t\t<input type=\"hidden\" name=\"redirect_to\" value=\"https:\/\/www.eurocytology.eu\/de\/wp-json\/wp\/v2\/course\/5108\/\" \/>\n\t\t\t<\/p><\/form><p class=\"cbxwpbookmark-guest-register\">No account yet? <a href=\"https:\/\/www.eurocytology.eu\/de\/register\/?redirect_to=https%3A%2F%2Fwww.eurocytology.eu%2Fde%2Fwp-json%2Fwp%2Fv2%2Fcourse%2F5108%2F\">Register<\/a><\/p><\/div><\/div><\/div><p>Grundlagen des Screenings Wenngleich es sicher diverse \u00e4hnliche Autorschaften gab, entsprechen die Kriterien f\u00fcr das zytologische Screening auch heute noch im Wesentlichen jenen die von Wilson &amp; Jungner aufgestellt wurden (1968) (Abbildung 5.1).&nbsp;&nbsp; Diese Grundlagen wurden k\u00fcrzlich von Andermann et al. (2008) um die Tatsache revidiert, dass HPV-Hochrisikost\u00e4mme als notwendige Ursache f\u00fcr die Entstehung von [&hellip;]<\/p>\n","protected":false},"featured_media":0,"parent":5099,"menu_order":0,"template":"","meta":[],"tags":[],"course_area":[120],"authors":[],"class_list":["post-5108","course","type-course","status-publish","hentry","course_area-zervixzytologie"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>5. 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