This content is also available in:
English 
Español
Tato kategorie ozna?uje adekvátní vzorky s bu?kami charakteristickými pro karcinom nebo jinou malignitu. Malignita by nikdy nem?la být diagnostikována na základ? pouze jednoho kritéria. Kombinace parametr? jmenovaných v následující tabulce je vždy nutná k dosažení diagnózy.
| Criterion | Benign | Malignant |
|---|---|---|
| General characteristics | ||
| Cellularity | Usually poor or moderate | Usually high |
| Cell to cell cohesion | Good with large defined clusters of cells | Poor with cell separation resulting in dissociated cells with cytoplasm or small groups of cells |
| Cell arrangement | Even, usually in flat sheets (monolayer) | Irregular with overlapping and three-dimensional arrangement |
| Cell types | Mixtures of epithelial, myoepithelial and other cells with fragments of stroma | Usually uniform cell population |
| Bipolar (elliptical) naked nuclei | Present, often in high numbers | Not conspicuous |
| Background | Generally clean except in inflammatory conditions | Occasionally with necrotic debris and sometimes inflammatory cells including macrophages |
| Nuclear characteristics | ||
| Size (in relation to red blood cell (RBC) diameter) | Small | Variable, often large, depending on tumour type |
| Pleomorphism | Rare | Common |
| Nuclear membranes (Pap stain) | Smooth | Irregular with indentations |
| Nucleoli (Pap stain) | Indistinct or small and single | Variable but may be prominent, large and multiple |
| Chromatin (Pap stain) | Smooth or fine | Clumped and may be irregular |
| Additional features | Apocrine metaplasia, foamy macrophages | Mucin, intracytoplasmic lumina |
(Modified from: GUIDELINES FOR NON-OPERATIVE DIAGNOSTIC PROCEDURES AND REPORTING IN BREAST CANCER SCREENING. NHSBSP Publication No 50 June 2001). |
||
V mnoha jiných evropských zemích jsou diagnostické standardy mamárních FNA cytologických vzork? kódovány s užitím pouze ?ty? kategorií:
- Inadekvátní
- Benigní
- Suspektní a
- Maligní
Porovnání evropské a U. K. klasifikace ukazuje, že není rozdílu v “následujícím diagnostickém postupu” mezi U.K. C3, C4 a C5 kategoriemi a suspektní/maligní, nebo? vyžadují histopatologické ov??ení.